• TFCH2002
  • Organic Chemistry 2

  • Credits (ECTS): 5
  • Food Science and Environmental Health

Modules are delivered
as part of a programme.
To apply for the
programme,
see the DIT website

Overview

Module Description

The module is designed to deliver a better understanding of the properties and reactions of Carbonyl compounds, Carboxylic acid derivatives, Carbonyl alpha-reactions, Carbonyl condensation reactions and Amines. The module is also designed to develop an ability to interpret spectral data and to build on the knowledge of Organic Chemistry acquired in level 1by imparting an appreciation of structural interpretation and of Carbonyl group chemistry.

Indicative Syllabus

Carbonyl compounds.
Overview of their structure and preparation. Nucleophilic addition reactions of aldehydes and ketones.
Relative reactivity of aldehydes and ketones.Imine and enemine formation. The Wolff-Kishner reaction. Acetal formation. The Wittig reaction. The Cannizarro reaction. Conjugate nucleophilic addition to an a,b- unsaturated carbonyl groups.
Carboxylic acid derivatives
Mechanism of nucleophilic acyl substitution reactions. Mechanism of esterification, ester hydrolysis by acid and base.
Carbonyl alpha-substitution reactions
Keto-enol tautomerism. The mechanism of alpha- substituion reactions. Hell Volhard Zelinsky reaction. Enolate ion formation. And their reactivity.
Carbonyl condensation reactions
Mechanism of carbonyl condensation reactions. Synthesis of enones. Intramolecular aldol reactions.
The Claison condensation reaction and mixed Claison reactions. The Dieckman cyclization, The Michael reaction The Stork enamine reaction.
Amines
Mechanism of reductive amination of a ketone. Mechanism of the Hoffman rearrangement of an amide to an amine.
Structure determination
Mass Spectrometry and the interpretation of a mass spectra. Infrared spectra and their interpretation Nuclear Magnetic Resonance Spectroscopy. Chemical shifts. Spin- Spin splitting patterns in H1 NMR Uses of NMR. 13C NMR spectroscopy. Characteristics and uses.
Conjugated dienes and UV spectroscopys. Molecular orbitals and conjugated dienes. Electrophilic additions to conjugated dienes Allylic carbocations. The Diels - Alder cycloaddition reaction. Structure determination in conjugated systems usinf UV spectroscopy.

Total Contact Teaching Hours:48

Please note that the catalogue is provided as a guide to modules in DIT. Not all modules listed will necessarily be offered every year and new modules may also be added. Information subject to change. For detail on specific programmes/modules please contact the relevant School directly.