Grainne Scanlon

phone: +353 1402 4933




Current Research

Neurodegenerative diseases of the retina such as age related macular degeneration (AMD) and diabetic retinopathy are significant causes of blindness worldwide. The relationship between AMD and macular pigment optical density (MPOD) has been widely reported, however, only a small number of studies have focused on MPOD and carotenoid intake in diabetes mellitus, a condition similarly known to cause oxidative damage in the retina. Diabetes, a lifelong progressive disease, is the result of the body’s inability to produce insulin or use insulin to its full potential and is characterized by high circulating glucose. Chronic hyperglycaemia causes oxidative stress, which results in microvascular complications at the retina. Macular pigment, a powerful antioxidant and blue light filter selectively located at the macula has been shown to be lower in diabetes.


Given the importance of macular pigment in preventative eye care, my research sought to further clarify the causal mechanisms and the metabolic permutations associated with lower macular pigment in diabetes. A primary research objective is to investigate the optical density of macular pigment in Type 1 and Type 2 diabetics and compare levels with normal controls. Another focus is to investigate determinants of macular pigment in a diabetic population as part of a large randomly selected sample from the Republic of Ireland (part of The Irish Longitudinal Study on Ageing [TILDA]), looking at anthropometric and serum biomarkers associated with MPOD.


Back to Top

     Find us on Facebook      Follow us on Twitter      Follow us on LinkedIn

Member of the European University Association