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Aidan D. Meade BSc MSc PhD MInstP

Brief Biography

BSc in Experimental Physics from University College Dublin in 1997.

MSc in Physical Sciences in Medicine from Trinity College Dublin, 2000.

PhD in Physics from Dublin Institute of Techology, 2010 with a thesis entitled "Spectroscopic and chemometric approaches to radiobiological analysis".

Member of the Institute of Physics, the Radiation Research Society (US) and the Association of Radiation Research (UK).

Previously employed as a Medical Physicist in the Department of Medical Physics and Bioengineering at St. James's Hospital (1997 to 2002). Joined staff of School of Physics, DIT in December 2002.

Teaching Interests

General Medical Physics and Clinical Measurement. Radiation Protection and Radiobiology. Non-Ionising Radiation. Nuclear and Particle Physics.

Research Interests

Radiobiology. Biophotonics. Multivariate modelling and data mining techniques.

On secondment from September 2008 to September 2010 as Project Coordinator under the HEA PRTLI Cycle 4 funded National Biophotonics and Imaging Platform at the Focas Institute.

Peer Reviewed Publications

C. Walsh, A. Dowling, A. D. Meade and J. Malone, Subjective and Objective Measures of Image Quality in Digital Fluoroscopy, Radiation Protection Dosimetry, 117,1-3, 34-37, 2006;

A.D. Meade, P. Knief, F.M Lyng, H.J. Byrne, Growth substrate induced functional changes elucidated by FTIR and Raman spectroscopy in in-vitro cultured human keratinocytes, Analytical and Bioanalytical Chemistry, 387 (5), 1717-1728, 2007;

F.M. Lyng, E.Ó Faoláin, J. Conroy, A.D. Meade, P. Knief, B. Duffy, M.B. Hunter, J.M. Byrne, P. Kelehan and H.J. Byrne, Vibrational Spectroscopy for Cervical Cancer Pathology, from biochemical analysis to diagnostic tool, Experimental and Molecular Pathology, 82(2), 121-129, 2007;

P. Knief, C. Clarke, E. Herzog, M. Davoren, F. M. Lyng, A. D. Meade, and H. J. Byrne, "Raman spectroscopy – a potential platform for the rapid measurement of carbon nanotube-induced cytotoxicity," Analyst DOI: 10.1039/b821393c, 2009.

A. D. Meade, C. Clarke, H. J. Byrne, and F. M. Lyng, "Fourier Transform Infrared microspectroscopy and multivariate methods for radiobiological dosimetry " Radiation Research, 173, 225-237, (2010).

A. D. Meade, H. J. Byrne, and F. M. Lyng, "Spectroscopic and chemometric approaches to radiobiological analysis" Mutation Research – Reviews in Mutation Research, 704, 108-114, (2010).

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, and H. J. Byrne, "Studies of chemical fixation effects in human cell lines using micro-Raman spectroscopy," Analytical and Bioanalytical Chemistry, 396 (5), 1781-1791, (2010).

F. Bonnier, A.D. Meade, S. Merzha,  P. Knief, K. Bhattacharya, F.M. Lyng, H.J. Byrne, Three dimensional collagen gels as a cell culture matrix for the study of live cells by Raman spectroscopy, Analyst, DOI:10.1039/c0an00060d, (2010).

H. Nawaz, H. J. Byrne, P. Knief, O. Howe, F. Bonnier, F.M. Lyng, A.D. Meade, Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma cells, Analyst, DOI:10.1039/C0AN00541J, (2010).

K.M Ostrowska, A. Malkin, A.D. Meade, J.J .O’ Leary, C. Martin. C. Spillane, H.J. Byrne, F.M. Lyng, Investigation of the influence of high risk human papillomavirus on the biochemical composition of cervical cancer cells using Raman spectroscopy, Analyst, DOI: 10.1039/C0AN00571A, (2010).

F. Bonnier, P. Knief, B. Lim, A. D. Meade, J. Dorney, K. Bhattacharya, F. M. Lyng and H. J. Byrne, Imaging live cells grown on a three dimensional collagen matrix using Raman microspectroscopy, Analyst, DOI: 10.1039/c0an00539h (2010).

F. Bonnier, A. Mehmood, P. Knief, A. D. Meade, W. Hornebeck, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T. C. Lee, F. M. Lyng and H. J. Byrne, In vitro analysis of immersed human tissues by Raman microspectroscopy, Journal of Raman Spectroscopy, DOI 10.1002/jrs.2825 (2010).

Proceedings Publications (full papers)

A.D. Meade, A. Dowling, C.L. Walsh and J.F. Malone, “Proposed Amendments to Equipment Standards for Dosimetry Instrumentation in Interventional Radiology”, International Atomic Energy Agency Proceedings, International Symposium on Standards and Codes of Practice in Medical Radiation Dosimetry, IAEA CN-96 44P, 421-427, 2003;

A.D. Meade, H.J. Byrne, F.M Lyng, Correlation of spectroscopic and biochemical assays post-ionising radiation exposure in human skin cell analogues, Proceedings of SPIE, 5826, 397-405, 2005;

Meade A.D., Clarke, C., Bonnier, F., Poon, K., Garcia, A., Knief, P., Ostrowska, K., Salford, L., Nawaz, H., Lyng F.M., Byrne, H.J., Functional and Pathological analysis of biological systems using vibrational spectroscopy with chemometric and heuristic approaches, WHISPERS: First Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing, IEEE Conference Proceedings, DOI: 10.1109/WHISPERS.2009.5288989, 2009.

Proceedings Abstracts (recent)

  • Meade A.D., Clarke C., Knief P., Byrne, H.J. , Lyng F.M., Selection of preprocessing methodology for multivariate regression of cellular FTIR and Raman spectra in radiobiological analyses, Irish Chemometrics Society Annual Scientific Meeting, University College Dublin, 16th April 2010.
  • Meade A.D., Broderick A., Lambkin, H., Muksinova K.N., Kirillova E.N., Revina V.S., Unterreiner V., Sockalingum G.D., Manfait M., Byrne, H.J., Lyng F.M., Detection of ionizing radiation damage in irradiated lung tissue using Fourier Transform Infrared microspectroscopy, Association for Radiation Research Annual Scientific Meeting, Oxford, 2010.
  • Nawaz, H, Meade, A.D., Lyng F.M., Byrne H.J., Raman spectroscopy for the evaluation of antincancer agents, Irish Institute for Metal Based Drugs Annual Scientific Meeting, DIT, 26thNovember 2009.
  • Meade A.D., Byrne, H.J., Lyng, F.M., Spectroscopic and Chemometric Approaches to Radiobiological Analysis, Association for Radiation Research Annual Scientific Meeting, Glasgow, 2009.
  • Raman spectroscopy – a platform for the rapid measurement of carbon nanotube-induced cytotoxicity, P. Knief, C. Clarke, E. Herzog, M. Davoren, F.M. Lyng, A.D. Meade, and H.J. Byrne, XLIV Zakopane School of Physics, International Symposium , “Breaking Frontiers: Submicron Structures in Physics and Biology”, 18th - 23rd May, 2009, Zakopane, Poland
  • Meade A.D., Byrne, H.J., Lyng, F.M., Spectroscopic and Chemometric Approaches to Radiobiological Analysis, European Science Federation and European Molecular Biology Organisation Joint Syposium: “Spatiotemporal Radiation Biology – Transdisciplinary Approaches for Biomedical Applications”, St. Feliu de Guixols, Costa Brava, 2009.
  • Meade A.D., Clarke, C., Bonnier, F., Poon, K., Garcia, A., Knief, P., Ostrowska, K., Salford, L., Nawaz, H., Lyng F.M., Byrne, H.J., Functional and Pathological analysis of biological systems using vibrational spectroscopy with chemometric and heuristic approaches, WHISPERS: First Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing, Grenoble, 2009.
  • Raman imaging for the investigation of the action of anti-cancer agents, Haq Nawaz, Franck Bonnier, Aidan Meade, Hugh J. Byrne, Fiona Lyng, SPEC 2008, Sao Jose dos Campos, Sao Paulo, Brazil, October 25-29, 2008.
  • Spectroscopic imaging of Quantum Dot cellular interaction, Lorenzo Salford, Franck Bonnier, Aidan Meade, Hugh J. Byrne, Fiona Lyng, SPEC 2008, Sao Jose dos Campos, Sao Paulo, Brazil, October 25-29, 2008.
  • Raman spectroscopy – a platform for the rapid measurement of carbon nanotube induced cytotoxicity, P. Knief, C. Clarke, E. Herzog, M. Davoren, F.M. Lyng, A.D. Meade, and H.J. Byrne, SPEC 2008, Sao Jose dos Campos, Sao Paulo, Brazil, October 25-29, 2008.
  • Skin Characterisation by Infrared Spectroscopy, Syed Mehmood Ali, Aidan Meade, Franck Bonnier, Hugh J. Byrne, Fiona Lyng, SPEC 2008, Sao Jose dos Campos, Sao Paulo, Brazil, October 25-29, 2008.
  • Biodosimetry and Biochemical Analyses of Radiobiological Response using Vibrational Spectroscopy”, Meade A.D., Clarke,C., Byrne, H.J., Lyng F.M., Annual Scientific Meeting of the Radiation Research Society, Massachusetts Convention Centre, Boston, USA, October 2008.
  • Raman spectroscopy of Carbon Nanotubes in Biological Systems – A Potential Alternative Toxicity Probe, P. Knief, E. Herzog, M. Davoren, F.M. Lyng, A.D. Meade, H. J. Byrne, European Conference on the Spectroscopy of Biological Molecules, Bobigny, Paris, September 2007.
  • Optical Vibrational Spectroscopy in the Analysis of Radiobiological Effects at the Cellular Level, Meade A.D., Sockalingum, G.D., Jeannesson, P., McClean, B, Manfait, M., Byrne, H.J. , Lyng F.M., European Conference on the Spectroscopy of Biological Molecules, Bobigny, Paris, September 2007.
  • Optical Analyses of Radiobiological Effects in Irradiated Cellular Systems, Meade A.D., Sockalingum, G.D., Jeannesson, P., McClean, B, Manfait, M., Byrne, H.J. , Lyng F.M, International Congress of Radiation Research, San Francisco, July 2007.