This site uses a number of third party cookies. By continuing to use this site you consent to the use of cookies in accordance with our Cookie Policy



  • Jella KK, Moriarty R, McClean B, Byrne HJ, Lyng FM (2018) Reactive oxygen species and nitric oxide signaling in bystander cells. PLoS ONE 13(4): e0195371.
  • Mohamed H. Ali, Fazle, Rakib, Khalid Al-Saad, Rafif Al-Saady, Fiona M. Lyng, Erik Goormaghtigh, A simple model for cell type recognition using 2D-correlation analysis of FTIR images from breast cancer tissue, Journal of Molecular Structure, 2018  1163, 472-479
  • Traynor D, Duraipandian S, Martin CM, O'Leary JJ, Lyng FM. Improved removal of blood contamination from ThinPrep cervical cytology samples for Raman spectroscopic analysis  J Biomed Opt. 2018  23(5):1-8. doi: 10.1117/1.JBO.23.5.055001 .
  • Aidan D. Meade, Adrian Maguire, Jane Bryant, Daniel Cullen, Dinesh Medipally, Lisa White, Brendan McClean, Laura Shields, John Armstrong, Mary Dunne, Emma Noone, Shirley Bradshaw, Marie Finn, Aoife M. Shannon, Orla Howe & Fiona M. Lyng (2018) Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy,International Journal of Radiation Biology, DOI: 10.1080/09553002.2018.1451006


  • Traynor D, Kearney P, Ramos I, Martin CM, O'Leary JJ, Lyng FM.  A study of hormonal effects in cervical smear samples using Raman spectroscopy.  J Biophotonics. 2017 Dec 7. doi: 10.1002/jbio.201700240
  • Carvalho LFCS, Bonnier F, Tellez C, dos Santos L, O´Callaghan K, O´Sullivan J, Soares LES, Flint S, Martin AA, Lyng FM and Byrne HJ, Raman spectroscopic analysis of oral cells in the high wavenumber region.  Exp Mol Pathol (2017) 103 (3)  255-262
  • P. Kearney, D. Traynor, F. Bonnier, F.M. Lyng, J.J. O’Leary, C.M. Martin, Raman spectral signatures of cervical exfoliated cells from liquid-based cytology samples, J. Biomed. Opt. 22(10), 105008 (2017), doi: 10.1117/1.JBO.22.10.105008. 
  • O. Ibrahim, A. Maguire, A. D. Meade, S. Flint, M. Toner, H. J. Byrne, and F. M. Lyng,  Improved protocols for pre-processing Raman spectra of formalin fixed paraffin preserved tissue sections. Anal. Methods, 9, 32, 4709-4717, 2017, DOI:10.1039/C6AY03308C
  • I.R. Ramos, F.M. Lyng, I.U Rehman, B. Sharrack & M.N. Woodroofe (2017): The use of vibrational spectroscopy to study the pathogenesis of multiple sclerosis and other neurological conditions, Applied Spectroscopy Reviews, 52:10, 868-882, DOI: 10.1080/05704928.2017.1336450
  • I. Behl, G. Calado, O. Ibrahim, A. Malkin, S. Flint, H.J. Byrne, F.M. Lyng, Development of methodology for Raman microspectroscopic analysis of oral exfoliated cells, Analytical Methods 2017, 9, 937 – 948
  • Medipally DK, Maguire A, Bryant J, Armstrong J, Dunne M, Finn M, Lyng FM, Meade AD. Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients. Analyst. 2017;142(8):1216-1226. doi: 10.1039/c6an02100j.
  • Ainsbury E, Badie C, Barnard S, Manning G, Moquet J, Abend M, Antunes AC, Barrios L, Bassinet C, Beinke C, Bortolin E, Bossin L, Bricknell C, Brzoska K, Buraczewska I, Castaño CH, Cemusová Z, Christiansson M, Cordero SM, Cosler G, Monaca SD, Desangles F, Discher M, Dominguez I, Doucha-Senf S, Eakins J, Fattibene P, Filippi S, Frenzel M, Georgieva D, Gregoire E, Guogyte K, Hadjidekova V, Hadjiiska L, Hristova R, Karakosta M, Kis E, Kriehuber R, Lee J, Lloyd D, Lumniczky K, Lyng F, Macaeva E, Majewski M, Vanda Martins S, McKeever SW, Meade A, Medipally D, Meschini R, M'kacher R, Gil OM, Montero A, Moreno M, Noditi M, Oestreicher U, Oskamp D, Palitti F, Palma V, Pantelias G, Pateux J, Patrono C, Pepe G, Port M, Prieto MJ, Quattrini MC, Quintens R, Ricoul M, Roy L, Sabatier L, Sebastià N, Sholom S, Sommer S, Staynova A, Strunz S, Terzoudi G, Testa A, Trompier F, Valente M, Hoey OV, Veronese I, Wojcik A, Woda C.  Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons. Int J Radiat Biol. 2017 Jan;93(1):99-109.  doi: 10.1080/09553002.2016.1206233
  • Kulka U, Abend M, Ainsbury E, Badie C, Barquinero JF, Barrios L, Beinke C, Bortolin E, Cucu A, De Amicis A, Domínguez I, Fattibene P, Frøvig AM, Gregoire E, Guogyte K, Hadjidekova V, Jaworska A, Kriehuber R, Lindholm C, Lloyd D, Lumniczky K, Lyng F, Meschini R, Mörtl S, Della Monaca S, Monteiro Gil O, Montoro A, Moquet J, Moreno M, Oestreicher U, Palitti F, Pantelias G, Patrono C, Piqueret-Stephan L, Port M, Prieto MJ, Quintens R, Ricoul M, Romm H, Roy L, Sáfrány G, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Thierens H, Turai I, Trompier F, Valente M, Vaz P, Voisin P, Vral A, Woda C, Zafiropoulos D, Wojcik A. RENEB - Running the European Network of biological dosimetry and physical retrospective dosimetry.  Int J Radiat Biol. 2017 Jan;93(1):2-14. 10.1080/09553002.2016.123023


  • Baker MJ, Goodacre R, Sammon C, Marques MP, Gardner P, Tipping W, Sulé-Suso J, Wood B, Byrne HJ, Hermes M, Matousek P, Campbell CJ, El-Mashtoly S, Frost J, Phillips C, Diem M, Kohler A, Lau K, Kazarian S, Petrich W, Lloyd G, Delfino I, Cinque G, Isabelle M, Stone N, Kendall C, Jamieson L, Perez-Guaita D, Clark L, Gerwert K, Notingher I, Quaroni L, Bhargava R, Meade A, Lyng F. Single cell analysis/data handling: general discussion, Faraday Discuss. 2016 Jun 23;187:299-327
  • Ramos IR, Meade AD, Ibrahim O, Byrne HJ, McMenamin M, McKenna M, Malkin A, Lyng FM, Raman spectroscopy for cytopathology of exfoliated cervical cells, Faraday Discussions 2016, 187, 187-198, DOI: 10.1039/C5FD00197H
  • Meade A.D, Howe O., Untereiner V., Sockalingum G.D., Byrne H.J. and Lyng F.M., Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes Faraday Discussions 2016, 187, 213-234, DOI: 10.1039/C5FD00208G
  • Singh, S.P., Ibrahim, O., Byrne, H. J., Mikkonen, J. W., Koistinen, A. P., Kullaa, A. M., Lyng, F. M. (2016), Recent advances in optical diagnosis of oral cancers: Review and future perspectives. Head Neck, 38: E2403–E2411. doi: 10.1002/hed.24293


  • Lyng FM, Traynor D, Ramos IRM, Bonnier F, Byrne HJ. Raman spectroscopy for screening and diagnosis of cervical cancer, Analytical and Bioanalytical Chemistry 2015, 407(27):8279-89. doi: 10.1007/s00216-015-8946-1. 
  • Carvalho LFCS, Bonnier F, O´Callaghan K, O´Sullivan J, Flint S, Byrne HJ and Lyng FM, Raman micro spectroscopy for rapid screening or oral squamous cell carcinoma and dysplasia, Exp Mol Pathol 2015 98(3):502-509 doi: 10.1016/j.yexmp.2015.03.027
  • Maguire A., Vega-Carrascal I., Bryant J., WhiteL., Howe O., Lyng F. M. and Meade A. D. , Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy Analyst 2015 140(7):2473-81. doi: 10.1039/c4an01887g.
  • Maguire, A., Vegacarrascal, I., White, L., Howe, O., Lyng, F.M., Meade, A.D. Analyses of low dose ionising radiation effects ex – vivo in peripheral blood lymphocytes with Raman spectroscopy. Radiat. Res.  2015 183(4):407-416
  • RamosIRM, MalkinA, LyngFM, Current advances in the application of Raman spectroscopy for molecular diagnosis of cervical cancer, BioMed Research International 2015 Article ID 561242, doi:10.1155/2015/561242
  • Lyng FM, Ramos IRM, Ibrahim O, Byrne HJ. Vibrational Microspectroscopy for Cancer Screening. Applied Sciences. 2015; 5(1):23-35, doi:10.3390/app5010023


  • Rashid N., Nawaz H., Poon K.W.C., BonnierF., Bakhiet  S., MartinC.,  O’LearyJ.J, ByrneH.J. and. Lyng F.M. Raman microspectroscopy for the early detection of pre-malignant changes in cervical tissue. Exp Mol Pathol 2014  97(3):554-64. doi: 10.1016/j.yexmp.2014.10.013
  • Shields, L, Vega-Carrascal, I., Singleton, S, Lyng, F.M, McClean, B.Cell Survival and DNA damage in normal prostate cells irradiated out-of-field, Radiat Res. 2014  182(5):499-506. doi: 10.1667/RR13777.1
  • Bonnier F, Traynor D, Kearney P, Clarke C, Knief P,  Martin C,  O'Leary JJ, Byrne HJ  and Lyng F, Processing ThinPrep cervical cytological samples for Raman spectroscopic analysis, Anal. Methods, 2014, 6, 7831
  • Jella KK, Rani S, O’Driscoll L, McClean B, Byrne HJ, Lyng FM, Exosomes are involved in mediating radiation induced bystander signalling in human keratinocyte cells, Radiat Res 2014 181(2):138-45


  •  S. M. Ali, F. Bonnier, K. Ptasinski, H. Lambkin, K. Flynn, F.M. Lyng, H.J. Byrne, Raman Spectroscopic mapping for the analysis of solar radiation induced skin damage, Analyst, (2013) 138(14):3946-56
  • S.M. Ali, F. Bonnier, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T.C. Lee, F.M. Lyng, H.J. Byrne, A comparison of Raman, FTIR and ATR-FTIR micro spectroscopy for imaging human skin tissue sections, Analytical Methods, 5, 2281-2291 (2013)
  • Furlong H, Mothersill C, Lyng FM, Howe O, Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect. Mutat Res. 2013;741-742:35-43
  • Syed M. Ali; Franck Bonnier; Ali Tfayli; Helen Lambkin; Kathleen Flynn; Vincent McDonagh; Claragh Healy; T. Clive Lee; Fiona M. Lyng; Hugh J. Byrne, Raman spectroscopic analysis of human skin tissue sections ex-vivo: evaluation of the effects of tissue processing and dewaxing  J. Biomed. Opt. 18 (6), 061202;  doi: 10.1117/1.JBO.18.6.061202 
  • Jella KK, Garcia A, McClean B, Byrne HJ, Lyng FM.  Cell death pathways in directly irradiated cells and cells exposed to medium from irradiated cells. Int J Radiat Biol. 2013;89(3):182-90.


  • Lyng FM, Desplanques M, Jella KK, Garcia A, McClean B., The importance of serum serotonin levels in the measurement of radiation-induced bystander cell death in HaCaT cells. Int J Radiat Biol. 2012, 88(10):770-2.
  • Irons SL, Serra V, Bowler D, Chapman K, Militi S, Lyng F, Kadhim M. The effect of genetic background and dose on non-targeted effects of radiation, Int J Radiat Biol. 2012; 88(10):735-42
  • Mothersill C, Antonelli F, Dahle J, Dini V, Hegyesi H, Iliakis G, Kämäräinen K, Launonen V, Lumniczky K, Lyng F, Safrany G, Salomaa S, Schilling-Tóth B, Tabocchini A, Kadhim MA. A laboratory inter-comparison of the importance of serum serotonin levels in the measurement of a range of radiation-induced bystander effects: Overview of study and results presentation. Int J Radiat Biol. 2012 ;88(10):763-9.
  • Poon KW, Lyng FM, Knief P, Howe O, Meade AD, Curtin JF, Byrne HJ, Vaughan J.  Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy. Analyst. 2012 137(8):1807-1814
  • Bonnier F., Ali S.M., Knief P., Lambkin H., Flynn K., McDonagh V., Healy C., Lee T.C., Lyng F.M., Byrne H.J., Analysis of human skin tissue by Raman microspectroscopy: Dealing with the background, Vibrational Spectroscopy 61 (2012) 124– 132


  • Nash ME, Carroll WM, Nikolskaya N, Yang R, O' Connell C, Gorelov AV, Dockery P, Liptrot C, Lyng F, Garcia A, Rochev YA. Straightforward, One Step Fabrication of Ultra-Thin Thermoresponsive Films from Commercially Available pNIPAm for Cell Culture ACS Appl Mater Interfaces. 2011 3(6) 1980-1990   
  • Nawaz H, Bonnier F, Meade AD, Lyng FM, Byrne HJ.  Comparison of subcellular responses for the evaluation and prediction of the chemotherapeutic response to cisplatin in lung adenocarcinoma using Raman spectroscopy  Analyst. 2011 136(12):2450-63
  • Zanchetta LM, Garcia A, Lyng F, Walsh J, Murphy JE. Mitophagy and mitochondrial morphology in human melanoma-derived cells post exposure to simulated sunlight, Int J Radiat Biology 2011 87(5):506-1
  • Lyng FM, Howe OL, McClean B. Reactive oxygen species-induced release of signalling factors in irradiated cells triggers membrane signalling and calcium influx in bystander cells. Int J Radiat Biol. 2011 87 (7)  683-695
  • Ostrowska KM, Garcia A, Meade AD, Malkin A, Okewumi I, O'Leary JJ, Martin C, Byrne HJ, Lyng FM. Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells. Analyst. 2011 136(7):1365-73.


  • Zanchetta LM, Kirk D, Lyng F, Walsh J, Murphy JE. Cell-density-dependent changes in mitochondrial membrane potential and reactive oxygen species production in human skin cells post sunlight exposure. Photodermatol Photoimmunol Photomed. 2010  26(6):311-7.  
  • Bonnier F., Mehmood A., Knief P., Meade A. D., Hornebeck W., Lambkin H., Flynn K., McDonagh V., Healy C., Lee T. C., Lyng F. M. and Byrne H. J., In vitro analysis of immersed human tissues by Raman microspectroscopy, Journal of Raman Spectroscopy 2010, 42(8)  1711-1711   
  • Maguire A, Morrissey B, Walsh JE, Lyng FM. Medium mediated effects increase cell killing in a human keratinocyte cell line exposed to solar simulated radiation Int J Radiat Biology 2010  87(1):98-111
  • Ostrowska KM, Malkin A, Meade A, O'Leary J, Martin C, Spillane C, Byrne HJ, Lyng FM. Investigation of the influence of high-risk human papillomavirus on the biochemical composition of cervical cancer cells using vibrational spectroscopy. Analyst 135(12):3087-3093 2010
  • Bonnier F, Knief P, Lim B, Meade AD, Dorney J, Bhattacharya K, Lyng FM, Byrne HJ. Imaging live cells grown on a three dimensional collagen matrix using Raman microspectroscopy. Analyst  135(12):3169-3177 2010
  • NawazN, Bonnier F, Knief P, Howe O, Lyng FM, Meade AD, Byrne HJ, Evaluation of the potential of Raman Microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma, Analyst 135(12):3070-3076 2010
  • Mukherjee SP, Lyng FM, Garcia A, Davoren M, Byrne HJ. Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells Toxicol Appl Pharmacol. 2010 248(3):259-68
  • Nugent S, Mothersill CE, Seymour C, McClean B, Lyng FM, Murphy JE., Altered mitochondrial function and genome frequency post exposure to g-radiation and bystander factors Int. J. Radiat. Biol. 2010,  86, 829–841
  • Naha PC, Bhattacharya K, Tenuta T, Dawson KA, Lynch I, Gracia A, Lyng FM, Byrne HJ. Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). Toxicol Lett. 2010 198(2):134-43
  • Naha PC, Davoren M, Lyng FM, and Byrne HJ,  Reactive Oxygen Species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells.  Toxicology and Applied Pharmacology 2010 246(1-2):91-9
  • Bonnier F, Meade AD, Merzha S, Knief P, Bhattacharya K, Lyng FM, Byrne HJ Three dimensional collagen gels as a cell culture matrix for the study of live cells by Raman spectroscopy. Analyst. 2010  135(7):1697-703
  • M. J. Baker, C. Clarke, D. Démoulin, J. M. Nicholson, F. M. Lyng, H. J. Byrne, C. A. Hart, M. D. Brown, N. W. Clarke and P. Gardner, An investigation of the RWPE prostate derived family of cell lines using FTIR spectroscopy, Analyst, 2010 135(5):887-94
  • Maguire A, Lyng FM, Walsh JE. Solar simulated radiation induced cell death depends on spectral distribution and irradiance but not output delivery. Radiat Prot Dosimetry. 2010  140(2):147-57
  • Meade AD, Clarke C, Draux F, SockalingumGD, ManfaitM, LyngFM, Byrne HJ, A study of chemical fixation effects in human cell lines using micro-Raman spectroscopy, Analytical and Bioanalytical Chemistry 2010 396(5):1781-91.
  • Meade AD, Byrne HJ, Lyng FM, Spectroscopic and Chemometric Approaches to Radiobiological Analyses, Mutation Research Review 2010 704(1-3):108-114
  • Meade AD, Clarke C, Byrne HJ, Lyng FM, Fourier Transform Infrared microspectroscopy and multivariate methods for biological dosimetry  Radiation Research 2010 173(2):225-37. 
  • Cogan N, Baird DM, Phillips R, Crompton L, Caldwell M, Rubio MA, Newson R, Lyng F, Case CP, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase  Mutation Research  2010 683(1-2):1-8.
  • Gorman S, Tosetto M, Dunlop A, Lyng F, Howe O, Sheahan K, O’Donoghue D, Hyland J, Mulcahy H, O’Sullivan J.  Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.  Mutation Research  2010 669(1-2):131-8.